Reviewed, UniProtKB/Swiss-Prot Q969T7 (5NT3L_HUMAN)

Names and origin

Protein names

Recommended name:
    Cytosolic 5'-nucleotidase III-like protein
      Short name=cN-III-like protein
    EC=3.1.3.5

Gene names

Name:

NT5C3L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Can act both as nucleotidase and as phosphotransferase By similarity.
Catalytic activity	A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.
Subcellular location	CytoplasmPotential.
Sequence similarities	Belongs to the pyrimidine 5'-nucleotidase family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Ligand	Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase Transferase
Gene Ontology (GO)
Biological process	nucleotide metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Cytosolic 5'-nucleotidase III-like protein		PRO_0000328948
Regions
	Region	148 – 149	2	Substrate binding By similarity
Sites
	Active site	33	1	Nucleophile By similarity
	Active site	35	1	Proton donor By similarity
	Metal binding	33	1	Magnesium By similarity
	Metal binding	35	1	Magnesium; via carbonyl oxygen By similarity
	Metal binding	222	1	Magnesium By similarity
	Binding site	197	1	Substrate By similarity
Natural variations
	Natural variant	201	1	V → A: dbSNP rs1046403.		VAR_042582
	Natural variant	205	1	C → S: dbSNP rs1046404.		VAR_042583

Sequences

	Sequence		Length	Mass (Da)
	Q969T7-1 [UniParc]. Last modified November 23, 2004. Version 2. Checksum: 742348D3845813E0	FASTA	292	33,573
	10 20 30 40 50 60 MKATVLMRQP GRVQEIVGAL RKGGGDRLQV ISDFDMTLSR FAYNGKRCPS SYNILDNSKI 70 80 90 100 110 120 ISEECRKELT ALLHHYYPIE IDPHRTVKEK LPHMVEWWTK AHNLLCQQKI QKFQIAQVVR 130 140 150 160 170 180 ESNAMLREGY KTFFNTLYHN NIPLFIFSAG IGDILEEIIR QMKVFHPNIH IVSNYMDFNE 190 200 210 220 230 240 DGFLQGFKGQ LIHTYNKNSS VCENCGYFQQ LEGKTNVILL GDSIGDLTMA DGVPGVQNIL 250 260 270 280 290 KIGFLNDKVE ERRERYMDSY DIVLEKDETL DVVNGLLQHI LCQGVQLEMQ GP

References

[1]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed: 16625196] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver, Lung and Testis.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC091172 Genomic DNA. No translation available. CH471152 Genomic DNA. Translation: EAW60771.1. BC013742 mRNA. Translation: AAH13742.2. BC014132 mRNA. Translation: AAH14132.2. BC016971 mRNA. Translation: AAH16971.2. BC067788 mRNA. Translation: AAH67788.1.
RefSeq	NP_443167.3.
UniGene	Hs.237536
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000141698. Homo sapiens. [Contig view]
GeneID	115024.
KEGG	hsa:115024.
Organism-specific databases
HGNC	HGNC:28300. NT5C3L.
PharmGKB	PA142671245.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q969T7.
HOVERGEN	Q969T7.
Gene expression databases
ArrayExpress	Q969T7.
CleanEx	HS_NT5C3L.
Family and domain databases
InterPro	IPR006434. HAD-SF_hydro_IE. [Graphical view]
PANTHER	PTHR13045. HAD-SF_hydro_IE. 1 hit.
Pfam	PF05822. UMPH-1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01544. HAD-SF-IE. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	79498.

Entry information

Entry name

5NT3L_HUMAN

Accession

Primary (citable) accession number: Q969T7
Secondary accession number(s): A8MWB9, Q7L3B7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	November 23, 2004
Last modified:	November 4, 2008
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)