Reviewed, UniProtKB/Swiss-Prot Q52V10 (CYC_SAISC)

Names and origin

Protein names

Recommended name:
    Cytochrome c

Gene names

Name:

CYCS

Organism

Saimiri sciureus (Common squirrel monkey)

Taxonomic identifier

9521 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Platyrrhini › Cebidae › Saimiriinae › Saimiri

Protein attributes

Sequence length	105 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain By similarity.
Subcellular location	Mitochondrion matrixBy similarity.
Post-translational modification	Binds 1 heme group per subunit By similarity.
Sequence similarities	Belongs to the cytochrome c family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Mitochondrion
Ligand	Heme Iron Metal-binding
PTM	Acetylation
Gene Ontology (GO)
Biological process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrial respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 105	104	Cytochrome c		PRO_0000108233
Sites
	Metal binding	19	1	Iron (heme axial ligand) By similarity
	Metal binding	81	1	Iron (heme axial ligand) By similarity
	Binding site	15	1	Heme (covalent) By similarity
	Binding site	18	1	Heme (covalent) By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylglycine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q52V10-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: A0BF06836BE50192	FASTA	105	11,790
	10 20 30 40 50 60 MGDVEKGKRI FIQKCSQCHT VEKGGKHKTG PNLHGLFGRK TGQAAGFTYT EANKNKGIIW 70 80 90 100 GEDTLMEYLE NPKKYIPGTK MIFVGIKKKG EREDLIAYLK KATNE

References

[1]

"Rapid electrostatic evolution at the binding site for cytochrome c on cytochrome c oxidase in anthropoid primates." Schmidt T.R., Wildman D.E., Uddin M., Opazo J.C., Goodman M., Grossman L.I. Proc. Natl. Acad. Sci. U.S.A. 102:6379-6384(2005) [PubMed: 15851671] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Web resources

Protein Spotlight

Life shuttle - Issue 76 of November 2006

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY918493 Genomic DNA. Translation: AAY17032.1.
3D structure databases
SMR	Q52V10. Positions 1-104, 2-105.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q52V10.
Family and domain databases
InterPro	IPR009056. Cyt_c_monohaem. IPR003088. Cyt_CI. IPR002327. Cyt_CIAB. [Graphical view]
Gene3D	G3DSA:1.10.760.10. Cytochrome_c_R. 1 hit.
PANTHER	PTHR11961. Cyt_CIAB. 1 hit.
Pfam	PF00034. Cytochrom_C. 1 hit. [Graphical view]
PRINTS	PR00604. CYTCHRMECIAB.
ProDom	PD010841. Cyt_c550. 1 hit. PD000375. Cyt_CIAB. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS51007. CYTC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYC_SAISC

Accession

Primary (citable) accession number: Q52V10

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	January 23, 2007
Last modified:	November 25, 2008
This is version 31 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)