Reviewed, UniProtKB/Swiss-Prot Q09165 (DIG1_CAEEL)

Names and origin

Protein names

Recommended name:
    Mesocentin

Gene names

Name:	dig-1
ORF Names:	K07E12.1

Organism

Caenorhabditis elegans [Complete proteome]

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	13100 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Encodes an adhesion molecule involved in sensory map formation. Functions during sensory process development in the nervous system.
Subcellular location	Secreted › extracellular space › extracellular matrix.
Sequence similarities	Contains 2 EGF-like domains. Contains 11 fibronectin type-III domains. Contains 7 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Sushi (CCP/SCR) domain. Contains 4 VWFA domains.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Extracellular matrix Secreted
Domain	EGF-like domain Immunoglobulin domain Repeat Signal Sushi
Molecular function	Developmental protein
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell adhesion Inferred from electronic annotation. Source: UniProtKB-KW gonad development Inferred from mutant phenotype. Source: WormBase hermaphrodite genitalia development Inferred from mutant phenotype. Source: WormBase nervous system development Inferred from mutant phenotype. Source: WormBase
Cellular component	proteinaceous extracellular matrix Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 13100	13076	Mesocentin		PRO_0000233334
Regions
	Domain	162 – 222	61	Sushi
	Domain	225 – 263	39	EGF-like 1
	Domain	305 – 392	88	Ig-like C2-type 1
	Domain	394 – 488	95	Fibronectin type-III 1
	Domain	491 – 577	87	Ig-like C2-type 2
	Domain	581 – 674	94	Fibronectin type-III 2
	Domain	681 – 778	98	Ig-like C2-type 3
	Domain	782 – 875	94	Fibronectin type-III 3
	Domain	892 – 983	92	Ig-like C2-type 4
	Domain	991 – 1091	101	Fibronectin type-III 4
	Domain	1094 – 1194	101	Fibronectin type-III 5
	Domain	1203 – 1280	78	Ig-like C2-type 5
	Domain	1284 – 1381	98	Fibronectin type-III 6
	Domain	1386 – 1490	105	Fibronectin type-III 7
	Domain	1500 – 1576	77	Ig-like C2-type 6
	Domain	1582 – 1694	113	Fibronectin type-III 8
	Domain	1699 – 1803	105	Fibronectin type-III 9
	Domain	1810 – 1904	95	Ig-like C2-type 7
	Domain	2005 – 2097	93	Fibronectin type-III 10
	Domain	6599 – 6787	189	VWFA 1
	Domain	12167 – 12341	175	VWFA 2
	Domain	12379 – 12557	179	VWFA 3
	Domain	12609 – 12780	172	VWFA 4
	Domain	12817 – 12905	89	Fibronectin type-III 11
	Domain	12988 – 13029	42	EGF-like 2; calcium-binding Potential
	Compositional bias	6894 – 6898	5	Poly-Glu
	Compositional bias	7613 – 7617	5	Poly-Glu
	Compositional bias	8387 – 8391	5	Poly-Glu
	Compositional bias	9431 – 9435	5	Poly-Glu
	Compositional bias	10150 – 10154	5	Poly-Glu
Amino acid modifications
	Glycosylation	70	1	N-linked (GlcNAc...) Potential
	Glycosylation	178	1	N-linked (GlcNAc...) Potential
	Glycosylation	324	1	N-linked (GlcNAc...)
	Glycosylation	384	1	N-linked (GlcNAc...)
	Glycosylation	518	1	N-linked (GlcNAc...)
	Glycosylation	575	1	N-linked (GlcNAc...)
	Glycosylation	841	1	N-linked (GlcNAc...)
	Glycosylation	931	1	N-linked (GlcNAc...) Potential
	Glycosylation	1112	1	N-linked (GlcNAc...) Potential
	Glycosylation	1211	1	N-linked (GlcNAc...) Potential
	Glycosylation	1399	1	N-linked (GlcNAc...) Potential
	Glycosylation	1612	1	N-linked (GlcNAc...) Potential
	Glycosylation	1840	1	N-linked (GlcNAc...) Potential
	Glycosylation	1879	1	N-linked (GlcNAc...) Potential
	Glycosylation	1898	1	N-linked (GlcNAc...) Potential
	Glycosylation	8810	1	N-linked (GlcNAc...) Potential
	Glycosylation	10555	1	N-linked (GlcNAc...) Potential
	Glycosylation	10570	1	N-linked (GlcNAc...) Potential
	Glycosylation	12294	1	N-linked (GlcNAc...)
	Glycosylation	12478	1	N-linked (GlcNAc...)
	Glycosylation	12840	1	N-linked (GlcNAc...) Potential
	Glycosylation	12843	1	N-linked (GlcNAc...)
	Glycosylation	12895	1	N-linked (GlcNAc...) Potential
	Glycosylation	12913	1	N-linked (GlcNAc...) Potential
	Disulfide bond	193 ↔ 220		By similarity
	Disulfide bond	327 ↔ 374		By similarity
	Disulfide bond	517 ↔ 561		By similarity
	Disulfide bond	705 ↔ 762		By similarity
	Disulfide bond	1226 ↔ 1264		By similarity
	Disulfide bond	1523 ↔ 1562		By similarity
	Disulfide bond	1839 ↔ 1888		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q09165-1 [UniParc]. Last modified March 1, 2003. Version 2. Checksum: E13DCBF28C7EA6FE	FASTA	13,100	1,373,302
	10 20 30 40 50 60 MGGRNWLFRS AVLVSTLLTC ISIAQELLPS IEVESLAQDL QIQEWMRTLR RVKRAPTRNN 70 80 90 100 110 120 RPEPVVVGRN GTGKCVISAD RASHFCGMEE EVSAPPIPPP DEGKCIISKA SGREICYPSY 130 140 150 160 170 180 SQLDTSCTDV TGQSSNGLVV PPVVPHATVR AMAFVPPDNL RRLIIQYYRQ QGKHQPKNAT 190 200 210 220 230 240 FSPKSFLFVK YHCDYGYEMV DEVDTMFCQD KKWVMTPPMC RGQGLCAADN GGCSHTCISY 250 260 270 280 290 300 NDEKIECKCP RGMTLDVDEK TCIKPIPKSL CRSLSGCTCN GITETQFACS CGDNKQKCLL 310 320 330 340 350 360 IAGPPRIYIE PQGPYEVAPG GNINISCTSV AYPFPDIYWF KNQKVNTDGP DQNTLRASQI 370 380 390 400 410 420 LIIKEIYRNE EFTCVSDNIH GSANRTVSIV VTGPGSAPHL KSASAGRTSL TVRWEPPSII 430 440 450 460 470 480 NRPITTYTLY YTNNPQQPVK NWKKLEVKEP TREVAIPDLR PDTAYYIRVR ANDPLGPGKL 490 500 510 520 530 540 GNQVQIKTLK PAVRPYVNIV EGDEIRVPPM TAFEIDCNVT RADPVPVLVW LHKGRPLNKG 550 560 570 580 590 600 SKTQHIKMKN GGVLESTQFS CVAENEAGKS TKKINVTVTG PSAPERIRYQ IDGDKVTLQW 610 620 630 640 650 660 EPPQITNGPM AGYDVFYTED PSLPRDQWKV HHIDDPNART TTVLRLNEKT PYTFVIVGRN 670 680 690 700 710 720 RLGPGLPSAP FTATTWLAAK PPVVQLEPSE EMTKEPSNDE MIIECGAQGV PKPKIIWLWS 730 740 750 760 770 780 GTLIEDGKEE FRVYDTTPTD AQDRTRSKLI AQSTTRSGVA TCQAVNSEGS DEKKVPVKIL 790 800 810 820 830 840 GPGSAPLGIT PTPMHTGFDV AWKPPKVTNG RITDYVVYYS KDPDAPLSDW ESKTVPADTR 850 860 870 880 890 900 NLTVNVDDED TPYVVKVQAR TDDGPGIISE AYEVTTGRKQ VPLSVRLEIA DPSVDPSTGE 910 920 930 940 950 960 TIVEPTQPIH FRCVADGRPM PSVSYSWLPI NASESGDEPV PIPIHSDDSQ PHHYNSIQVY 970 980 990 1000 1010 1020 STTATKRILL CQARNPDGTV DDRHVFIVNK PGSAPQNPEV IVDPDNRVTI TWQPPKYPNG 1030 1040 1050 1060 1070 1080 EITSYNVYIT GDPSLPVDQW QVFPVDDVTD PKLVLQRGAL QPETPYFVKI AAVNPHGEGI 1090 1100 1110 1120 1130 1140 HTDPKHFDTV SGAPIDAPTD VLPSVSIDNT VNITWSPPTQ PLGPIKSYTV YFAPEYDDSD 1150 1160 1170 1180 1190 1200 FKTWQRISVD APDGADHGEV TLPKEQFNPN TPYKIRISAT NDLSEGPASD PVRFETGSGE 1210 1220 1230 1240 1250 1260 IPPTITLDPS NSTYTVEPLG AATITCTATG VPQPKVHWIK ANGETVDSAT LQLYDLVKDT 1270 1280 1290 1300 1310 1320 SATCVAENNA GKTQEAVSIQ VTGPGTAPNE IVLLPMPNQE INVEWTSPDE VNGQITNYII 1330 1340 1350 1360 1370 1380 HYGEISEDGS EPATWDQVTI ARDDVNHKLA NLEPKKTYAI RVQAVSDRGP GVISAPQVIK 1390 1400 1410 1420 1430 1440 TLPLAPQAIT NPIIQVHPNN SVTIEFTPPD DPENPGKKVK DFVIQYTTDE EPDDESVWKE 1450 1460 1470 1480 1490 1500 LKFTDPDDTD DTTIVSIDGE NFNPDTKYNT RIIARGEIDS QPNEPTLFAT GDGVIAPSQP 1510 1520 1530 1540 1550 1560 SFNVDTEDGV IRVPAGTDYT IKCVSEGYPA PDVRWVDSHG NQLSDGPLLR IIDIRKTLNA 1570 1580 1590 1600 1610 1620 KCLAENRGGL KETDLTIFVA GPGTAPENIQ LTANKPTTIS VQYEVPSIPN GNISKYIIYY 1630 1640 1650 1660 1670 1680 TPLDDQDPDH QLGQVQTKPI SDWQNVHDMN DGVEGPRKVD IKDFVSTDTA YAVVVQAIND 1690 1700 1710 1720 1730 1740 DGPGPYSNQY TIRTMSRARE GPPVELRVEP DGQRSAVAQW KEPVTSDVPP IGYEIYYVRG 1750 1760 1770 1780 1790 1800 DKSVEEDDSA GLNDWIKISI DDPTKLTHKI QNLLLPDTDY VFKMRAIYPD GPSVFSEPCI 1810 1820 1830 1840 1850 1860 MKTLPDGNAP YIQISTGDNG VEGSTTIQIL PGSQMTIACN ATGIPLPQVK WIKAGNYEID 1870 1880 1890 1900 1910 1920 PSRVDADGNH AQFSLQVANI TEDTTFNCVA QNPLGHANWT INVNLIEGLE PNWRDDFVTS 1930 1940 1950 1960 1970 1980 KSDGGQIVLV FNDELPEYLK PPNEWTIQYT DDAEQPKDQW ESIPSGGAPL TRVEVPNMNP 1990 2000 2010 2020 2030 2040 GTFYYLVVDN PEKGIQTPTL VVMTPKPPSD IRFGKNNDDE QIVDFKPAVA SEPIKEYTIS 2050 2060 2070 2080 2090 2100 VWPSTDPSNV KKFTTPADVT SGVVVDGLEP DTEYNVQVAA EFYEGEELAS EPVTVKTPPR 2110 2120 2130 2140 2150 2160 DVSCECDHGC AFEMNEDAGT MEPKCYCHGG FHLTSDGKSC ERDEEDDATS QAVLQVTPPS 2170 2180 2190 2200 2210 2220 ITTKVAPEEL LTGSSGEVDS TPETLSPVVG PDGKPLVLDK KGKPIDSSGK PVKFDENGDP 2230 2240 2250 2260 2270 2280 IAPEGTKLEK NDNGEWVYPL VDRNGKPLPV DENNKPIITV IDKDGRVVTE TDDGTFVTSD 2290 2300 2310 2320 2330 2340 GKQVEVDDLG RPLDEDGNPY KTNENGQFVI SDVDGAVEGD DEEEQPQVIP LYVVDVDDDG 2350 2360 2370 2380 2390 2400 KYLDEDGNEI PVNEDGDPID VNGKPLEKNE DGKFVKPKES TQETPQPTKI TIVSPDGTPL 2410 2420 2430 2440 2450 2460 PTDASGSPIG LDGQPVPTDA SGKPLAKDGS PLPTDNNGNY VILPSSKNSV DSQPTDDAGR 2470 2480 2490 2500 2510 2520 VIYPVVLPDG SPLATDSTGN FVNRHGDIVE RDDEGKPMGP DGQLLPTDAS GNYIYPVTGP 2530 2540 2550 2560 2570 2580 NDEVLPTDAN GNPIYPVVGP DGTPLPTDAS GAIVGPDGQP IPTDSNGKPL SKEGYPLPVD 2590 2600 2610 2620 2630 2640 NQGNYILLPT EIDAAQSLPT DDAGMPVYPI VKPDGTPLAT DSTGSFINDN GEIIEKDDEG 2650 2660 2670 2680 2690 2700 RPFGPDGLIL PTDASGNYIY PAMGLDGQPL ATDASGNYVL VSTEQTVTKS YPVDDSDITI 2710 2720 2730 2740 2750 2760 HPIVNPDGTP LATDSTGSYV TEDGQIIEKD DEGRPLGPDG QVLPTDDSGN YIYPVAESGE 2770 2780 2790 2800 2810 2820 ETKPTDASGK TVYPVRGPDG TPLPTDASGA VIGPDGEVIP TDENGIPLSQ DGSPLPTDNQ 2830 2840 2850 2860 2870 2880 GNYILVLTSE TPTKTLPIDE SGNVVYPITK PDGTPLATDS TGSFVTEDGT IIAKDDEGKP 2890 2900 2910 2920 2930 2940 LGPDGEVLPT DASGNYVYPV TVSDEQTLPT DDTGKTVYPI RGPDGTPLPT DASGPVIGPD 2950 2960 2970 2980 2990 3000 GEIMPTDENG IPLSKDGTPL PTDNDGNYVI VPSDEETSKE LPIDDSGNVI YPITKPDGTP 3010 3020 3030 3040 3050 3060 LATDSTGSFV TEDGTIIEKD DEGKPLGPDG QILSTDASGN YVYPDPGLDS QILTTDVYGK 3070 3080 3090 3100 3110 3120 PIYTVIGPDG TALPTDASGA AIGPDGTPIS TDETGEPLDK DGSILPTDDY GNFVFVVSQE 3130 3140 3150 3160 3170 3180 LPTDAEVQTP ITKPDGTLLA TDSSGNYVND NGDIIEKDDE GKPLGPDGEV LPTDGTGNFI 3190 3200 3210 3220 3230 3240 YPATTSDGEV IPTDDSGKPL YTIRGPDGTP LPTDETGSAL GPDGEPISTD SSGKPLSKDG 3250 3260 3270 3280 3290 3300 SPLPTDNNGN YVLVPTDEST TKALPTDESG NVVIPITNPD GTSLATDSTG SFVTDDGQII 3310 3320 3330 3340 3350 3360 EKDDEGKPLG PDGAILPTDA SGNYIYPVVG PDGQALPTDE TGKTVYPVRG PDGTPLPTDA 3370 3380 3390 3400 3410 3420 SGAVMGPDGE PIPTDANGKP LSKDGSPLPT DASGNYVLVP SDEVTAKELP TDESGTIVYP 3430 3440 3450 3460 3470 3480 VTRADGTPLA TDSTGSFVTD DGQIIGKDDE GKPLGPDGQV LPTDDSGNYI YPAVGPDGQA 3490 3500 3510 3520 3530 3540 FPTDKSGKPL YPVRGPDGTS LPTDASGAAI GPDGEVIPTD ENGIPLDKDG SPLPTDASGN 3550 3560 3570 3580 3590 3600 YIIVPSGELT MASHPTDDTG NVIYPITKPD GTLLSTDSTG SFVTEDGQII EKDDEGKPLG 3610 3620 3630 3640 3650 3660 PNGEALPTDD LGNYIYPITD SDEQTSPTED VGTSVHLVRG PDGTPLPTDA SGSAIGPDGE 3670 3680 3690 3700 3710 3720 VIPTDENGVP LDKDGSPLPT DNNGNYVLVP TKESVTKILP TDDSEAVVHP ITRQDGTPLS 3730 3740 3750 3760 3770 3780 TDSTGNFVTD NGEIIEKDDE GRPVGPDGQV LSTDVSGNFV YPVTESPNDG EKPIHPVLGP 3790 3800 3810 3820 3830 3840 DGSPLPTDDS GAVIGPDGEV IPTDASGVPL SKLGLPLPTD SDGNYIILSS DTDVTKELPT 3850 3860 3870 3880 3890 3900 DDTGNVIYPI TKPDGTPLGT DTSGSFVSDD GQIIEKDDDG KPLGPDGQVL PTDATGNFIY 3910 3920 3930 3940 3950 3960 PVLGPDGQAL PTDESGKTVY PVRRPDGNPL PTDASGAVIG PGGEPIPTDS SGKPLSADGS 3970 3980 3990 4000 4010 4020 PLPTDASGNY VLVPSDEVTA KELSTDESGT IVYPVTRADG TPLATDSTGS FVTDEGQTIE 4030 4040 4050 4060 4070 4080 KDDEGKPLGP DGQVLPTYAS GNYIYPVIGP DGQALPTDES GKTVYPVRGP DGTPLPTDVS 4090 4100 4110 4120 4130 4140 GAVIGPDGEV IPTDSNGIPL SQDGTPLPTD NQGNYILVPT SETATKALPT DESGNVIYPI 4150 4160 4170 4180 4190 4200 TKADGTPLAT DSTGTFVTDD GQIIEKDDEG KPLGPDGQVL PTDDSGNYIY PVVGPDGQTD 4210 4220 4230 4240 4250 4260 ESGKTVYPVR GSHPTDDTGN VIYPITKPDG TLLATDSTGS FVTEDGQIIE KDDEGKPLGP 4270 4280 4290 4300 4310 4320 DGQVLPTDES GNYVYPEVKS DEQLLPTDHT GKTVYPVHGP DGTPLPTDDS GAIIGPDGEV 4330 4340 4350 4360 4370 4380 IPTDENGIPL SKDGSQLPTD NNGNYVLVPS DEGATKTHPT DETSDAVHPI TKPDGTPLAT 4390 4400 4410 4420 4430 4440 DSTGNFVTEN GDVITKDEEG KPLGPNGQIL PTDASGNYIY PVIGPDGQAL PTDESGKTVY 4450 4460 4470 4480 4490 4500 PVRGPDGTPL PTDASGAVIS PDGEVIPTDA NGIPLDKDGS PLPTDASGNY ILVPSEQDIT 4510 4520 4530 4540 4550 4560 KTLPTDDSGN VIYPITKPDG TSLATDSTGS FVTEGGEIVE RDEDGKPLGP DGQVLPTDAS 4570 4580 4590 4600 4610 4620 GNYIYPVVGP DGQVLPTDDT GKTVYPVYGP DGIPLSTDAS GAVIGPDGEP IPTDASGRPL 4630 4640 4650 4660 4670 4680 DKDGSFLSTD ASGNYILVPS DAPTNEAGPV VVQHQITRPD GTPLATDSSG HFVTEDGVII 4690 4700 4710 4720 4730 4740 ENDKEGRPIG ADGQVLPTDA SNNYIFTDVP TQGYAVFIPT DVVPIELEAP NCDQVDGRVD 4750 4760 4770 4780 4790 4800 TLLFVVESSH TSAPYLDTLK KLIENLLLTT PRDFLPKIGT LIYSATTEIT IDIGSYGDFK 4810 4820 4830 4840 4850 4860 ELFDSTNEIR EIGGIPDVTN ALRTAKMILE ETSRGDTLVL HLLASPMRTS SKVYTERIRA 4870 4880 4890 4900 4910 4920 LPNTRLIHLN EKQWAEDPNA VELLRSHLCI PSEVPLPSMM PTDASGNLLS IPTDEVVTDG 4930 4940 4950 4960 4970 4980 TPTDESGFVI YPITKPDGTP LATDSTGSFV TEDGQIIEKN EDGKPLGPDG QVLPTDNSGN 4990 5000 5010 5020 5030 5040 YIYPIVGPDG QALPTDASGK PIYPVRGPDG TPLPTDASGA VIGPDGEPIP TDASGKPLAQ 5050 5060 5070 5080 5090 5100 DGSPLPVDNE GNYIILPTQQ VDTKEYPTDE TGNVIVPITK PDGTLLPTDS TGSFVTENGD 5110 5120 5130 5140 5150 5160 RIEFNEEGKP LGPDGEVLAT DASGNYVYPG SVVEPTAEPQ EVTHGPDGQV LPTDASGKPI 5170 5180 5190 5200 5210 5220 YPVRGPDGIP LPTDASGAAI GPDGETIATD ENGIPLSKDG SPLPTDNTGN YVLVPSDEGA 5230 5240 5250 5260 5270 5280 TEEKPTQGSE SIVHPITKPD GTPLATDSTG SFVTDDDQVI AKDEDGKPIG PDGQVLPTDS 5290 5300 5310 5320 5330 5340 SGNYIYPVIG PDGQALPTDE SGKTVYPVRG PDGTPLSTDA SGAVIGSDGK PIPTDETGLP 5350 5360 5370 5380 5390 5400 LNKDGSPLPT DNDGNYILIP ADESVVKALP TDEAKEVYPI VQPDGTPLAT DSSGNFVTSS 5410 5420 5430 5440 5450 5460 GDIIDIDDEG KPLGPDGQAL PTDDSGNYIY PVIGPDGQAL PTDESGKTVY PIRGPDGTPL 5470 5480 5490 5500 5510 5520 PTDASGAVIG PDGEPIPTDA SGKPLSQDGS PLPTDASGNY ILVPSDGEVT KTLPTDDVGN 5530 5540 5550 5560 5570 5580 VIYPITKPDG TPLATDSTGS FVTDDGQIIE KDDEGKPLGP DGQVLSTDDS GNYIYPAVGP 5590 5600 5610 5620 5630 5640 NGQTIPTDDT GRTVYPVRGP DGTPLPTDAS GAVIGPDGEP IPTDASGKPL SADGSPLPTD 5650 5660 5670 5680 5690 5700 NNGNYVIVPT DGSTVKSHPT DDSGNTIYPV VNEDGTPLST DLSGNFLTNS GEIVDRDDEG 5710 5720 5730 5740 5750 5760 KPLGPDGQTL PTDASGNYVY LQKVEETTKP LPTDESGNIV YPITKPDGTP LATDSTGSFV 5770 5780 5790 5800 5810 5820 TEDGTVIEKD DEGKPVGPDG QVLPTDESGN YIYPDVTPDG QVQPTDVSGK PVYPVRGPDG 5830 5840 5850 5860 5870 5880 STLPTDASGA ALGPDGKPIP TDSNGVPLSE DGSPLPTDNQ GNYVLVPTSE TVTKSMPTDD 5890 5900 5910 5920 5930 5940 NRNVIYPITM SDGSLLSTDS TGSFVTEDGK VIEKDDEGKP LGPDGQVLPT DASGNYIYPV 5950 5960 5970 5980 5990 6000 HGQDGTPLPT DASGAVIGPD GSPLPTDDSG AVIGPDGEVI PTDSNGIPLN KDGLPLSTDA 6010 6020 6030 6040 6050 6060 SGNYIVVSAE QPGEEIKEIP ITKPDGTLLS TDSTGNFITE NGEIIERDDE GKPIGPDGQI 6070 6080 6090 6100 6110 6120 LPTDASGNYV YPVIGPDGQG LPTDESGKTI YPVRGPDGTP LPTDASGAVI GPDGEPIPTD 6130 6140 6150 6160 6170 6180 ASGKPLSQDG SLLPTDNNGN YVLLPSNEET TQGLTTDESV NVIYPITKPD GTPLATDSTG 6190 6200 6210 6220 6230 6240 NFVTDNGETI EKDEEGKPIG PDGQTLPTDD SGNYIYPVVG PDGQALPTDE SGKTIYPVHG 6250 6260 6270 6280 6290 6300 PDGTPLPTDA SGASIGPDGE PIPTDTSGKP LFKDGSPLPT DSNGNFIIVP SEKRMDEELP 6310 6320 6330 6340 6350 6360 TDDSGKIIYP ITKPDGTPLA SDSTGVFVTE DGTIIEKDDD GKPLGPDGQV LPTDASGNYI 6370 6380 6390 6400 6410 6420 YPIVGPDGKT QPTDESEKTP YPVHGPDGTP LPTDASGAVI GPDGEPIPTD ASGKPLSADG 6430 6440 6450 6460 6470 6480 SPLPTDNNGK YVLVPADEVT TKVLPTDDSG NVVHPITRPD GTPLGTDASG SFITDDGQAI 6490 6500 6510 6520 6530 6540 EKDDEGKPIG PDGQILPIDA SGNYIYPVIG PDGQALPTDE SGKTVYPVRG PDGTPLPTDA 6550 6560 6570 6580 6590 6600 SGAVIGLDGE PIPTDASGKP LSRNGSPLST DSSGNYIFVP TDDEKKDSKK CDISSSL