Reviewed, UniProtKB/Swiss-Prot P59990 (KR121_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin-associated protein 12-1
Alternative name(s):
    Keratin-associated protein 12.1
    High sulfur keratin-associated protein 12.1

Gene names

Name:	KRTAP12-1
Synonyms:	KAP12.1, KRTAP12.1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	96 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
Subunit structure	Interacts with hair keratins.
Tissue specificity	Expressed exclusively in a narrow region of the middle portion of hair fiber cuticle.
Sequence similarities	Belongs to the KRTAP type 12 family.

Ontologies

Keywords
Cellular component	Keratin
Domain	Repeat
Gene Ontology (GO)
Cellular component	keratin filament Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 96	96	Keratin-associated protein 12-1		PRO_0000185196
Regions
	Repeat	10 – 14	5	1
	Repeat	15 – 19	5	2
	Repeat	24 – 28	5	3
	Repeat	30 – 34	5	4
	Repeat	35 – 39	5	5
	Repeat	45 – 49	5	6
	Repeat	50 – 54	5	7
	Repeat	55 – 59	5	8
	Repeat	60 – 64	5	9
	Repeat	70 – 74	5	10
	Repeat	75 – 79	5	11
	Repeat	80 – 84	5	12
	Repeat	85 – 89	5	13
	Repeat	90 – 94	5	14
	Region	10 – 94	85	14 X 5 AA approximate repeats

Sequences

	Sequence		Length	Mass (Da)
	P59990-1 [UniParc]. Last modified November 7, 2003. Version 1. Checksum: 9360F4462E1036C8	FASTA	96	9,737
	10 20 30 40 50 60 MCHTSCSSGC QPACCAPSPC QASCYIPVGC QSSVCVPVSF KPAVCVPVRC QSSVCVPVSC 70 80 90 RPVVYAAPSC QSSGCCQPSC TSVLCRPISC STPSCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21." Rogers M.A., Langbein L., Winter H., Beckmann I., Praetzel S., Schweizer J. J. Invest. Dermatol. 122:147-158(2004) [PubMed: 14962103] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Scalp.
[2]	"A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3." Shibuya K., Obayashi I., Asakawa S., Minoshima S., Kudoh J., Shimizu N. Genomics 83:679-693(2004) [PubMed: 15028290] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hair root.
[3]	"The DNA sequence of human chromosome 21." Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S., Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M., Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A. , Menzel U., Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A., Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J., Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K., Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G., Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J., Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S., Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K., Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L. Nature 405:311-319(2000) [PubMed: 10830953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ566388 mRNA. Translation: CAD97468.1. AB076363 mRNA. Translation: BAD01550.1. AL773604 Genomic DNA. No translation available. BC119713 mRNA. Translation: AAI19714.1. BC120942 mRNA. Translation: AAI20943.1. BC127648 mRNA. Translation: AAI27649.1.
RefSeq	NP_859014.1.
UniGene	Hs.688628
3D structure databases
ModBase	Search...
Proteomic databases
PeptideAtlas	P59990.
Genome annotation databases
Ensembl	ENSG00000187175. Homo sapiens. [Contig view]
GeneID	353332.
KEGG	hsa:353332.
Organism-specific databases
H-InvDB	HIX0040856.
HGNC	HGNC:20529. KRTAP12-1.
PharmGKB	PA134971238.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	P59990.
Gene expression databases
CleanEx	HS_KRTAP12-1.
Family and domain databases
InterPro	IPR002494. Keratin_B2. [Graphical view]
PANTHER	PTHR23262. Keratin_B2. 1 hit.
ProtoNet	Search...
Other Resources
NextBio	99786.

Entry information

Entry name

KR121_HUMAN

Accession

Primary (citable) accession number: P59990
Secondary accession number(s): Q0VAS3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	November 7, 2003
Last modified:	November 25, 2008
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)